is Partial Liquid Ventilation (PLV)? Why put
liquid into the lungs, isn't fluid buildup in the lungs part of the ARDS problem?
ventilation (PLV) involves filling the lungs with a fluid.
This fluid is perfluorocarbon, also called Liquivent or Perflubron. The liquid has some unique properties. It has a very low surface tension, similar to
surfactant, a substance that is produced in your lungs and prevents the alveoli from
collapsing and sticking together during exhalation. It
also has a high density, oxygen readily diffuses through it, and it may have some
anti-inflammatory properties. In PLV, the
lungs are filled with the liquid, the patient is then ventilated with a conventional
ventilator using a protective lung ventilation strategy.
This is called partial liquid ventilation.
The hope is that the liquid will help the transport of oxygen to parts of
the lung that are flooded and filled with debris, help remove this debris and open up more
alveoli improving lung function. The study of
PLV involves comparison to protocolized
strategy designed to minimize lung damage.
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